Nephrotic Syndrome Treatment

Conventional treatment for Nephrotic Syndrome is steroids and immunosuppressants, but they have a lot of side effects, and the disease gets relapse frequently. If you would like to try alternatives and get permanent treatment of the disease, systemic Chinese medicine will be a good choice for you. After a short period of treatment, edema will disappear completely, and proteinuria will turn negative.

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What if Steroids Do not Take Effect on MCD Patients

2019-03-16 17:09

What if Steroids Do not Take Effect on MCD PatientsMinimal Change Disease (MCD) patients are usually steroid-sensitive, but there are still some patients who are steroid-resistant. What if steroids do not take effect on MCD patients?

Steroid-resistant MCD is an important indication of renal biopsy. If the kidney biopsy is still MCD, the possible reasons are inadequate steroid dosage, reduction or withdrawal of drugs too quickly.

In addition, severe edema affects the absorption of drugs, which is also an important reason. For such patients, intravenous use of methylprednisolone can achieve significant results.

At the same time, we must pay attention to the delayed effect of steroid therapy. A group of 89 adult MCD patients were treated with steroids of standard course. 60% of them were relieved after 8 weeks, 76% were relieved after 16 weeks, and 81% were relieved after 16 weeks.

For steroid-resistant Nephrotic Syndrome patients, it is recommended to add cyclophosphamide (dose 2 mg/kg.d) or leukeran (0.1-0.2 mg/kg.d) for 8-12 weeks to increase and maintain the remission rate of some nephrotic syndrome patients. The side effects such as bone marrow suppression, liver and gonad damage and aggravation of infection should be paid attention to during the use.

As a second-line immunosuppressive drug, cyclosporine A (CsA) was administered twice at a starting dose of 5 mg/kg.d. The trough value of the drug concentration was monitored and maintained at 100-200 ng/ml, which was reduced slowly after 3 months.

More than 90% of patients can achieve complete or partial efficacy after using CsA. However, the biggest problem with CsA is the high recurrence rate after discontinuation.

Compared with CTX 63% long-term remission rate, CsA treatment has only 25% long-term remission rate. However, the long-term remission rate can be increased if the treatment can be gradually reduced and maintained for a longer period of time.

Some scholars did repeated renal biopsy 20 weeks after using CsA, and no obvious renal toxicity damage was found.

Because cyclosporine A is a lipophilic drug, which combines with low density and high density lipoprotein in the blood, in severe hyperlipidemia with Nephrotic Syndrome, the effective concentration of the drug in circulation may be affected, and attention should be paid to the control of blood lipids in patients.

In recent years, some new immunosuppressive agents (e.g., MMF, dosage 1.0-1.5g/d) and immunomodulators (e.g. levamisole, 2.5mg/kg taken every other day) have also been tried to treat steroid-resistant MCD, but their effectiveness and long-term remission rate need to be confirmed by large-scale clinical studies.

In addition, you should try Toxin-Removing Treatment for MCD. It can help you have a permanent control of the disease.

What if steroids do not take effect on MCD? Now you get the answer. For more information on MCD treatment, please leave a message below or contact online doctor.

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This is a girl from Saudi Arabic. After about half a month of treatment in our hospital, her leg edema disappeared, and the effect was very obvious.

Nephrotic Syndrome Patient from New Zealand Paid Second Visit to Our Hospital