Is Amoxicillin Safe for Nephrotic Syndrome Patients
Is amoxicillin safe for Nephrotic Syndrome patients? Amoxicillin is one penicillin-like antibiotic that can deal with various infections due to bacteria. However, if patients have kidney disease as well as Nephrotic Syndrome, they should pay highly attention to the use of amoxicillin.
As introduced by the pharmacist, 24%~33% of amoxicillin is metabolized in the liver after taking it, while 45%~68% of amoxicillin metabolism is discharged out by kidneys via urine. Additionally, some are eliminated by the biliary tract. Here, we can know kidneys affect the metabolism of amoxicillin largely.
If Nephrotic Syndrome patients’ kidney function level is still above 50% and they don’t have other contraindication, they can still take amoxicillin safely. If not, they should avoid or at least reduce their dosage.
When patients’ glomerular filtration rate (GFR) ranges from 10 ml/min to 50 ml/min, their dosing interphase should be 8~12 hours, while the dosing interphase should prolong to 12~16 hours once GFR is less than 10 ml/min. If Nephrotic Syndrome patients have begun hemodialysis instead of peritoneal dialysis, they can increase their dosage of amoxicillin to some extent. This is because hemodialysis can help eliminate some ingredients of this medication out of the body.
Since Nephrotic Syndrome is characterized by glomerular changes, any mistake of medication taking may worsen their illness condition. Besides, this kidney disease occurs more commonly in children, so doctors and parents should control the dosage tightly.
Besides amoxicillin, many other antibiotics are also used to deal with infections for kidney disease patients. If you or your child happens to have this condition, you can go to Antibiotics Suitable for Nephrotic Syndrome Patients to see which antibiotic is safe for you. Any question about today’s topic, welcome to contact us.
Tag: nephrotic syndrome treatment
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