Complications in Nephrotic Syndrome may occur as a part of the disease itself or as a consequence of drug treatment. The root cause is the loss of plasma proteins in the urine, which is due to the increasing permeability of the glomerular basement membrane. The common complications are as follows.
The main cause of infection is drugs, especially steroids and antibiotics. Common infections are acute upper respiratory infection, pneumonia, conjunctivitis, gingivitis, ulcer or intestinal and urinary infection.
Nephrotic Syndrome patients lose a large amount of protein with urine. As a result, their bodies’ defense mechanism ability declines. Besides, the use of steroids and antibiotics inhibits body’s own defence mechanism, providing a favorable environment for the growth of bacteria. Therefore, infections easily occur due to long-term use of steroids and antibiotics. Except infection, osteoporosis is another bad result.
The abnormal glomerular filtration can lead to loss of proteins which help prevent clotting. Swelling, lack of exercises, high cholesterol, fibrinogen accumulation and increased synthesis of factors V, VII, VIII, X are also the causes.
Acute kidney failure
Most Nephrotic Syndrome patients live wit hypovolemia and hypercoagulability because of suffering from heavy proteinuria, hypoproteinemia and hyperlipidemia. In addition, vomiting, diarrhea and the use of anti-hypertension drugs and diuretics, all may lead to decreasing renal blood perfusion, and then the glomerular filtration declines. Therefore, acute renal failure occurs. Moreover, renal interstitial edema and kidney tubular obstruction due to protein concentration may also induce acute kidney failure.
Because of hyperlipidemia and blood hypercoagulation, Nephrotic Syndrome patients are more likely to get cardiovascular disease. Coronary heart disease has been the third dangerous factor of the death causes for Nephrotic Syndrome patients.
As what I mentioned in the first paragraph, the complications of Nephrotic Syndrome can be divided into two categories, disease-associated and treatment-related. As for the treatment, it is important to start with early identification and appropriate therapies. Chinese medicine therapy is recommended by kidney disease doctors. Any questions, please consult our online experts or leave a message below.