Nephrotic Syndrome Prognosis and Life Expectancy

Minimal Change Disease is more common in children, according for 80%-90% of Nephrotic Syndrome in children, and less in adults. Without good control, it may progress into kidney failure.

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Minimal Change Disease May Cause Kidney Failure

2018-12-12 06:16

Minimal Change Disease May Cause Kidney FailureMinimal Change Disease is more common in children, according for 80%-90% of Nephrotic Syndrome in children, and less in adults.

The characteristics of children with minimal change disease (MCD) are obvious: large amount of proteinuria, low plasma albumin, edema, serous cavity effusion, and generally no high blood pressure.

90% of children with this kidney disease are easy to treat and do not suffer from renal failure. But 10 percent still have decreased kidney function and are at risk for uremia. After all, children are the hope of the family, and it should cause our attention.

Although minimal change disease is not a serious form of kidney disease, 20 to 30 percent of patients experience a moderate decrease in kidney function (about 25 percent). After albuminuria gets remission, kidney function can be restored to normal.

In addition, MCD can lead to more dangerous declines in kidney function: acute kidney failure, with a sudden surge in creatinine.

Acute renal failure (arf) occurs in MCD in the following ways:

1. Toxicity of large amount of proteinuria to renal tubules;

2. Serum albumin is lower than 20g/L;

3. Focal segmental glomerulosclerosis (FSGS), which is neglected during the initial renal biopsy;

4. Hypovolemia induced by diuretics;

5. ACEI or ARBs;

6. Non-steroidal anti-inflammatory drugs, such as ibuprofen, acetaminophen, aspirin and so on. they can cause damage to the renal interstitium;

7. Antibacterial drugs, such as gentamicin and other aminoglycoside antibiotics

8. Folk prescription drugs with nephrotoxicity

9. Excessive loss of urine protein causes hyperlipidemia and renal vein thrombosis

10. Nephrotoxicity of cyclosporine

11. Infection (e.g. peritonitis, cellulitis)

It can be seen that a small number of patients are acute renal failure caused by minimal change disease itself, and most of them are caused by external inducement to damage renal tubules in a special form.

When kidney failure occurs, support therapy such as withdrawal of nephrotoxic drugs and removal of acute factors should be taken to gain time. Kidney failure is relieved when glucocorticoids such as prednisone take effect and urine protein drops.

Note: the above material about minimal change disease may cause kidney failure is intended for informational purposes only. For specific suggestions, please consult a physician.

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