IgA nephropathy, also known as Berger's disease, is a kidney disease that occurs when an antibody called immunoglobulin A (IgA) lodges in your kidneys. This results in local inflammation that, over time, may hamper your kidneys’ ability to filter waste, excess water and electrolytes from your blood. Does IgA Nephropathy cause kidney enlargement? Yes, but not every time.
How does IgA Nephropathy cause kidney enlargement?
Many kidney diseases can cause an enlargement kidney. Nephritis, kidney stone, kidney cyst, Nephrotic Syndrome and Hydronephrosis can lead to an enlarged kidney under ultrasound. Why? IgA Nephropathy is characterized by immunoglobulin A deposition on the kidneys. That deposit will damage kidney function to maintain the water balance of the body. If the excessive fluid cannot be discharged out of the body, it will accumulate and cause swelling. Most of the patients will see their hands, legs, eyelids or ankles become puffy. That happens because water retention which will also occur in kidneys.
There is another reason why kidney enlarges with IgA Nephropathy. The accumulation of immunoglobulin A will cause inflammation of the kidney, and that is why the kidney becomes larger than normal size.
How to deal with kidney enlargement with IgA Nephropathy?
Normally, treatment differs from individual to individual. There are three situations:
- Treating symptoms or complications
Swelling and infection are the common factors leading to kidney enlargement. In clinic, doctor will prescribe some diuretics and antibiotics to reliever swelling and infection. These medicines are helpful for mild kidney enlargement. However, it may bring patients with IgA Nephropthy some side effects.
Immunotherapy is the latest treatment for autoimmune kidney damage which helps rebuild the underlying immune system and uses the immune system to fight against the kidney damage. This therapy has 6 steps, including immune diagnosis, immune blocking, immune tolerance, immune adjustment, immune protection, and immune clearance. This therapy aims at enhancing the immune system of the body, and then the immunoglobulin A deposition in mesangial area will be decreased. Moreover, no inflammatory reaction occurs, and finally kidney will be protected and improved. Thus, kidney enlargement will disappear over time.
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