Iga Nephropathy Prognosis and Life Expectancy

IgAN is the most common form of primary glomerulonephritis around the world. IgA Nephropathy tends to progress slowly, and in 25-30% of the patients will have chronic renal failure during a period of years or decades. The prognosis is extre

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Indicators of Poor IgA nephropathy Prognosis

2014-04-03 05:52

Indicators of Poor IgA nephropathy Prognosis IgAN is the most common form of primary glomerulonephritis around the world. IgA Nephropathy tends to progress slowly, and in 25-30% of the patients will have chronic renal failure during a period of years or decades. The prognosis is extremely variable based on patients’ own conditions

At present, indicators of poor prognosis include: persistent massive proteinuria, high serum creatinine at diagnosis, persistent microscopic hematuria, poorly controlled hypertension, and extensive glomerulosclerosis , etc.

Massive proteinurine:

If patients have persistent proteinurine more than 0.35 grams per day for more than 6 months , that’s a indicator of poor prognosis. Proteinurine may cause further damage to glomeruli, and the long-term damage may be irreversible.

High serum creatinine:

If patients are with a high serum creatinine at prognosis, these patients have already experienced severe kidney damage. Prognosis of these patients usually is unsatisfactory.

High blood pressure:

Generally, the accepted target blood pressure for IgA Nephropathy patients is about 125/75. For some patients, this may be very hard to achieve without multiple medications and a low-sodium diet. Persistent high blood pressure impairs glomeruli reducing its filter function, so chronic high blood pressure also counts as a factor of poor prognosis. However, in this case, the lower blood pressure may not be the better. With too low pressure, other health problems will occur.

High cholesterol:

Most kidney disease patients are more likely to have problems with narrow blood vessels than other people. As we know cholesterol is always related to blood vessel diseases, especially cardiovascular disease. Thus, keeping cholesterol level under control contributes to avoiding cardiovascular complications. Otherwise the prospect of patients’ condition are undesirable.

The above are negative factors to prognosis. Controlling these factors in appropriate levels would guarantee good prognosis for patients.

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