Hypertensive Nephropathy Treatment

There are 6 categories of anti-hypertensive drugs: 1. Angiotensin-converting enzyme inhibitor (ACEI) 2. Angiotensin receptor antagonist (ARB) 3. Calcium antagonist (CCB) 4. receptor blockers 5. receptor blockers 6. Diuretics

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7 Kinds of Medicine Cannot Be Used Together with Anti-hypertensive Drugs

2018-10-25 08:13

7 Kinds of Medicine Cannot Be Used Together with Anti-hypertensive DrugsThere are 6 categories of anti-hypertensive drugs:

1. Angiotensin-converting enzyme inhibitor (ACEI)

2. Angiotensin receptor antagonist (ARB)

3. Calcium antagonist (CCB)

4. β receptor blockers

5. α receptor blockers

6. Diuretics, including thiazide diuretics, loops diuretics and potassium preserving diuretics.

Some drugs can't be used together with antihypertensive drugs, and today we're going to talk about four of antihypertensive drugs, and the 7 kinds of medicines that can not be used together.

1. CCB

CCB drugs (such as nifedipine, felodipine and amlodipine) are mainly metabolized by liver CYP3A4, so drugs affecting CYP3A4 should not be used together with CCB drugs. For example,

-Strong inhibitory agents of CYP3A4: itraconazole, fluconazole, clarithromycin, etc.;

-CYP3A4 strong inducers, such as rifampicin, carbamazepine, phenobarbital, phenytoin, etc.

Amlodipine also has moderate inhibition of CYP3A4. When combined with simvastatin, the daily dose of simvastatin should be no more than 20 mg.

2. ARBs

ACEI includes enalapril, benazepril, fosinopril, etc., and ARBs include irbesartan, valsartan, losartan, telmisartan, etc. When combined with the following drugs, there are pharmacodynamic interactions:

(1) Potassium-sparing diuretics, if used together, can lead to hyperkalemia;

(2) Diabetic patients who use alikeilun will have a double blockage of the RASS system so as to increase the risk of hypotension, high blood potassium and deterioration of renal function, it is better to avoid being used together.

3. ACEI

Drugs that cannot be used in combination with ACEI include the above 2 of the ARBs, and the following (3) and (4):

(3) A combination with the enkephalin inhibitor shakubatol increases the risk of angioneurotic edema.

(4) A combination with non-steroidal anti-inflammatory drugs (NSAID) can reduce the effect of anti-hypertension due to sodium and water retention, and increase the risk of renal injury.

4. β receptor blockers

Lipid soluble β receptor blockers, such as propranolol and metoprolol (excluding water-soluble β receptor blockers, such as atenolol), are mainly metabolized by CYP2D6 in the body, so it will be affected by CYP2D6 inhibitors, such as propanone, fluoxetine and paroxetine. These drugs may slow down β receptor blocker's metabolism, causing severe bradycardia.

When you have to take many kinds of drugs for kidney disease, you should talk with your doctor. Do not take them without the instruction of doctors in case of further kidney damage. For more information on kidney disease treatment, please leave a message below or contact online doctor.

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