FSGS Symptoms

For FSGS patients, most of them have refractory proteinuria. Persistent proteinuria can speed up glomerulosclerosis and make kidney condition worse. Then how to reduce refractory proteinuria for FSGS patients? Read on to learn more.

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How to Reduce Refractory Proteinuria for FSGS Patients

2018-11-28 07:56

How to Reduce Refractory Proteinuria for FSGS PatientsFor FSGS patients, most of them have refractory proteinuria. Persistent proteinuria can speed up glomerulosclerosis and make kidney condition worse. Then how to reduce refractory proteinuria for FSGS patients? Read on to learn more information.

FSGS is divided into the primary, secondary and hereditary three categories. 100% of patients have proteinuria, 60% of patients have urinary protein more than 3.5g/day (a large amount of proteinuria), and 1/3 of patients have hypertension and kidney function damage at the onset of disease.

Without aggressive treatment, more than 50% of patients develop uremia within 5 to 10 years.

FSGS treatment:

1. Combined use of hormone and immunosuppressant

For example, 1mg/kg/day of prednisone (or 0.8 mg/kg/day of methylprednisone);

Plus immunosuppressants:

(1) 0.4-0.6 g of Cyclophosphamide at a time is preferred. Intravenous drip every other week. The total dose shall not exceed 0.1 ~ 0.15 g/kg.

(2) Or Cyclosporine is 4 ~ 5mg/kg/day, taken on an empty stomach for twice a day. After 2 to 3 months, the dosage can be reduced slowly. A small dosage of 3 mg/kg is maintained for a long time. The total time is about half a year.

(3) For patients with ineffective cyclosporine treatment, tacrolimus can be used 0.05 ~ 0.1 mg/kg per day, and the blood concentration is 5 ~ 10 ng/ml.

In the initial treatment, there may be no effect, because FSGS often needs 3 months of hormone + immunosuppressive therapy to have a significant effect.

Sixty percent of patients can be controlled with hormones and immunosuppressants.

2. Chinese medicine

We found that glomerulosclerosis belongs to phlegm turbidity and stagnation in traditional Chinese medicine, which requires traditional Chinese medicine treatment of activating blood, clearing collaterals and removing blood stasis. It can further reduce urine protein and prevent relapse.

3. Rituximab or plasma exchange

If you are the 40% that traditional Chinese medicine is also ineffective, you can try rituximab or plasma exchange. Both of these treatments are relatively expensive.

4. To prevent complications

In the treatment of refractory proteinuria, a variety of antihypertensive, lipid lowering, anticoagulation, antithrombotic treatment should be done to prevent the occurrence of dangerous complications.

With the above four treatment methods, refractory proteinuria can be brought under control.

Disclaimer: The above information is for educational purposes. For specific suggestions, please consult a physician.

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