FSGS refers to Focal Segmental Glomerulus Sclerosis, and it will cause damage in glomeruli partially, which means not all glomeruli will be damaged, and damage appears in some part of single glomerulus.
FSGS progresses slowly, but it often has bad reaction to hormone treatment, and it can cause kidney failure eventually. Well then, what are the causes of FSGS?
In fact, FSGS can be divided into primary FSGS and secondary FSGS, and they have very different causes, which means FSGS can be caused by various reasons.
Causes of primary FSGS:
The causes of primary FSGS mainly include gene mutation (like gene mutation of NPHS1, ACTN4, CD2AP, WT1, etc), various syndromes (like Denys-Drash, Frasier, Alport, etc), hereditary diabetes, Diffuse mesangial sclerosis, etc.
Causes of secondary FSGS:
·Virus: FSGS is often caused by HIV, B19 virus, etc.
·Medicines: medicines like heroin, interferon, lithium, pamidronate, etc, can also cause FSGS.
·Kidney tissues reducing: FSGS can also be caused by the reduction of kidney tissues, like solitary kidney, kidney dysplasia, reflux nephropathy, sequelae of renal cortical necrosis, chronic allograft nephropathy, etc.
·Blood shortage: many factors can cause the shortage of blood and oxygen in kidney, which can also cause patients to have FSGS. For example, blood shortage in kidney can be caused by factors like hypertensive kidney lesion, ischemic renal disease, cholesterol crystal embolism, catenulate red blood cell anemia, etc.
·Fat: fat can also FSGS.
As we can see, FSGS can be caused by various reasons, and patients should make sure what is the cause of their disease. Besides, FSGS patients’ condition will relapse in a short time after patients accept kidney transplant, which indicates it is a disease which has connection with many pathogenic factors.