Diabetic Nephropathy Treatment

When diabetes develops into Diabetic Nephropathy, your current hypoglycemic drugs may have to be changed. Which hypoglycemic drug is more appropriate for Diabetic Nephropathy patients? Read on to learn more information.

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Which Hypoglycemic Drug Is More Appropriate for Diabetic Nephropathy Patients

2019-03-30 17:12

Which Hypoglycemic Drug Is More Appropriate for Diabetic Nephropathy PatientsWhen diabetes develops into Diabetic Nephropathy, your current hypoglycemic drugs may have to be changed. Which hypoglycemic drug is more appropriate for Diabetic Nephropathy patients? Read on to learn more information.

According to statistics, diabetes is the leading cause of uremia, and it is also one of the main factors leading to the increase of uremia population. Diabetic Nephropathy is one of the typical complications of diabetes mellitus. Long-term poor control of blood sugar can cause abnormal blood flow in the body, trigger glomerular ultrafiltration, and lead to ischemia and hypoxia in the kidney due to high pressure of the kidney, then causing renal function damage.

Metformin

Metformin is the first-line drug for the treatment of diabetes mellitus and the basic drug for lowering blood sugar. Almost all patients with type 2 diabetes mellitus take this kind of medicine. It is mainly by reducing the liver’s sugar output and improving insulin resistance to play a hypoglycemic role. At the same time, it can also reduce weight and prevent cardiovascular diseases. But it also has some side effects, such as nausea, vomiting, dizziness, and a few people will have lactic acid acidosis.

Therefore, patients in the early stage of renal insufficiency need to reduce the dosage of such drugs. Metformin is forbidden in kidney patients whose glomerular filtration (GFR) rate is less than 45 m/min, including patients with late stage of renal insufficiency, Kidney Failure and uremia.

Sulfonylureas, glinides, insulin sensitizers

Sulfonylurea secretion enhancers, such as glipizide and gliclazide, can promote insulin release from islet beta cells and reduce blood sugar and glycosylated hemoglobin levels. Patients in stage 3 of diabetic nephropathy need to take reduced doses, patients in stage 4 and 5 are banned. Specific reduction needs to be based on the condition of the disease, and timely consultation with doctors when necessary.

The common medicines of glinide are repaglinide and nateglinide. They also have the function of stimulating insulin secretion. They are short-acting hypoglycemic drugs with obvious hypoglycemic effect. Patients in the first four stages of Chronic Kidney Disease (CKD) can take these drugs, but attention should be paid to monitoring renal function. Uremia patients, including dialysis patients, are not recommended to take them.

Insulin sensitizer is more suitable for diabetic patients with insulin resistance. It can improve fasting and postprandial blood sugar. Diabetic nephropathy patients should be cautious if they have edema and anemia. In addition, patients in stage 1-3 can take it. Patients with advanced renal insufficiency, renal failure and uremia can not use it.

DPP-4 inhibitor

Compared with metformin, this kind of drug is a newly developed drug on the market. It has the functions of enhancing insulin secretion, inhibiting pancreatic hyperglycemia secretion, delaying gastric emptying, and lowering blood pressure and weight. Now on the market include exenatide, liraglutide.

However, some side effects of these drugs need to be further studied. For patients whose glomerular filtration rate is less than 50 m/min, they can not be used, including patients with stage 3, stage 4 and stage 5 of nephropathy.

Again, we remind you that when taking antihypertensive drugs, in order to avoid drug damage to renal function, we must strictly abide by the doctor's advice, and do not use drugs arbitrarily.

Which hypoglycemic drug is more appropriate for Diabetic Nephropathy patients? Now you get the answer. For more information on Diabetic Nephropathy treatment, please leave a message below or contact online doctor.

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You can take a look at this patient's report. His creatinine was 1028 and urea level was 39.7 on 2018-12-11; creatinine level was reduced to 331 and urea was 16.1 on 2019-1-5. After about 25 days' treatment in our hospital, his creatinine level was reduced by 697, and urea was reduced by 23.6. Hope his condition gets better and better.

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It can make your urine foamy. Although it does not make you feel uncomfortable, it can impair your renal function and make your kidney disease worse. Conventional treatment such as steroids and immunosuppressants can hardly make it negative. In our hospital, systemic Chinese medicine treatment can help you turn it negative. Look at this picture, bubbles in urine become less and less with our treatment going on.