Diabetic Nephropathy Causes

Diabetic Nephropathy refers to a serious complication of diabetes. If left untreated, it will develop into kidney failure eventually. Learning about the causes and stages of diabetic kidney disease can be helpful. Causes of diabetic nephrop

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Causes And Stages of Diabetic Nephropathy

2014-04-02 09:30

Causes And Stages of Diabetic NephropathyDiabetic Nephropathy refers to a serious complication of diabetes. If left untreated, it will develop into kidney failure eventually. Learning about the causes and stages of diabetic kidney disease can be helpful.

Causes of diabetic nephropathy

Kidneys are consisted of millions of nephrons. And these nephrons can work together to filter metabolic products, toxins and extra fluid, etc out of the blood. However, when exposing to high blood sugar level for a long time, these tiny blood vessels will be damaged gradually. As a consequence, diabetic nephropathy occurs.

In addition to high blood sugar level, other factors including high blood pressure, hyperlipidemia, genetic factors are also associated with the onset of DN.

Stage of diabetic nephropathy

In clinical, diabetic nephropathy is divided into five categories:

Stage 1: This stage is also known as high filtration stage and the GFR value is usually above 150. According to the statistics, the size of kidney will increase by 20% and the endogenous creatinine clearance rate increases by 40%.

Stage 2: After about 18-24 months course of diabetes, the glomerular basement membrane will become thickened. And GFR level ranges from 130-150.

Stage 3: In stage 3, kidney damage mainly manifest as charge barrier of glomerular basement membrane. Due to this, microalbuminuria can occur correspondingly. Generally, the quantity of albumin varies from 30mg/dL to 300mg/dL.

Stage 4: When it progresses to this stage, there can be durative proteinuria. Besides, the glomerular filtration rate will drop rapidly. And symptoms like swelling, hypoproteinemia can also occur.

Stage 5: Also known as ESRD, the GFR level is lower than 20 and creatinine level is above 400. To expand the life span, dialysis or kidney transplant are commonly used.

After the above introduction, we belive you have formed a basic understanding about the causes and stages of diabetic nephropathy. For detailed information, please leave us a message below or feel free to consult with Online Doctor directly!

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