Nephrotic Range Proteinuria and IgA Nephropathy

IgA Nephropathy is one type of glomerulonephritis. Just like hematuria and hypertension, proteinuria is another common symptom of IgA Nephropathy. Nephrotic range proteinuria means the amount of protein in urine is more than 3.5g/24h. If this occurs, IgA Nephropathy must present Nephrotic Syndrome. Then, how to manage a large amount of proteinuria for IgA Nephropathy patients?

IgA Nephropathy is resulted from inflammatory reactions in kidneys caused by the deposits of IgA in glomerular mesangial area. When kidney filters, glomeruli, are unable to play their filtration function normally, protein may leak into the urine, forming proteinuria. If left untreated, a large amount of protein leakage can cause malnutrition, hypoproteinemia, hair loss, skin discoloration, less energy, and some other complications may appear.

How to manage nephrotic range proteinuria? Steroids and immunosuppressants are used commonly to treat IgA Nephropathy. They can inhibit inflammatory reactions through weakening immune system, so they can prevent protein from leaking into the urine and relieve proteinuria. However, only depending on these medicines, IgA Nephropathy may relapse again and again. What’s worse, some patients may even not respond to these medications.

To strengthen the therapeutic effects and control nephrotic range protein from the root, more systemic treatment is needed. Immunotherapy is one therapy that can help treat kidney disease completely caused by deposits of immune complexes as well as IgA.

This therapy has four great effects: removing deposit of IgA, rebuilding glomerular filtration barrier, regulating immune system, and repairing damaged kidney cells. Generally, after about one month’s treatment, IgA Nephropathy patients can feel their overall health improved largely. Accordingly, their proteinuria is eased from the root.

Now, we have got an overview understanding of nephrotic range proteinuria and its treatment. If you want to learn more methods to manage it, you can leave a message below. Therefore, kidney experts can give you suggestions in detail.

Tag: IgA Nephropathy IgA Nephropathy Symptoms IgA Nephropathy Immunotherapy

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